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  • Know-How

    Chemical Reactions

    We offer a broad variety of chemical transformations to address synthetic challenges from lab to multi-ton scale:

    • Acetylation / Acid chlorination / Acylation / Alcoholysis / Alkoxylation / Alkylation / Amides synthesis / Amines synthesis
    • Benzoylation
    • Condensation
    • Debenzylation / Dehalogenation / Dehydratation / Diazotation
    • Epoxydation / Esterification / Ethers synthesis
    • Halogenation / Hydrogenation / Hydrolysis / Hydroxylation
    • Mesylation
    • Oxidation / Optical resolutions
    • Reductions with iodides

    PharmaZell has the capabilities to run chemical reactions in broad temperatures ranging from -50 °C to 240 °C, with the ability to isolate starting materials and intermediates from natural sources. With our internal know-how and broad network of external specialists in distinctive fields, e.g. like enzymatic conversions and electrochemistry, we can address challenging chemistry in research, development, scale-up and production.

    Particle Design

    With our vast expertise in customizing particle sizes and extensive crystallization know-how, we produce a wide range of different API grades. For each project, we can offer polymorphic screening to uncover possible new polymorphs and to safeguard polymorphic process stability during scale-up and production. Each manufacturing site has hammer and jet mills on site, allowing milling of the drug substance to the desired particle size distribution.

    Continuous Improvement

    Our teams continuously review process performance after transfer to production in order to identify process improvement opportunities. These improvements allow us to stay ahead of the evolving needs of compendial/quality requirements, commercial/cost improvements and capacity gain needs.

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